Gamma-Glutamylcyclotransferase (GGCT) Antibody
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935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-GGCT
proveedor
Abbexareference
abx003774Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
GGCT Antibody is a Rabbit Polyclonal antibody against GGCT. The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Background
Gamma Glutamyl Cyclotransferase (GGCT) is an enzyme that plays a crucial role in glutathione metabolism by catalyzing the conversion of gamma-glutamyl peptides to 5-oxoproline and free amino acids. GGCT is involved in maintaining cellular redox balance and regulating glutathione homeostasis, which is essential for cellular protection against oxidative stress and detoxification processes. Dysregulation of GGCT activity has been linked to various pathological conditions, including cancer, where it is often upregulated and contributes to tumor proliferation and chemoresistance. Its role in the gamma-glutamyl cycle also makes it a potential target for therapeutic interventions in oxidative stress-related diseases.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Gamma-Glutamylcyclotransferase (GGCT)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
GGCT
dry ice
No
availability
Shipped within 5-10 working days.
alias
GGC,GCTG,CRF21,C7orf24,Cytochrome c-releasing factor 21
uniprot id
NCBI accession
NP_076956.1
note
Concentration: > 0.2 mg/ml -
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