Gamma-Adducin (ADD3) Antibody
52€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Gamma-Adducin (ADD3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013900
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against ADD3 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Gamma-Adducin (ADD3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UEY8 |
| Alias | ADDL,CPSQ3,ADDUCIN 3 |
| Background | Antibody anti-ADD3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ADD3 encodes gamma-adducin, a ubiquitously expressed cytoskeletal protein that cooperates with alpha- and beta-adducins to modulate the actin-spectrin network and stabilize cellular membranes. It is most abundantly expressed in the liver, kidneys, and vascular endothelium, where it regulates cell shape, motility, and membrane mechanical properties. Gamma-adducin is also implicated in intracellular signaling and vascular integrity, playing a role in processes such as angiogenesis and endothelial barrier function. Variants in ADD3 have been associated with conditions such as hypertension and vascular diseases due to its role in modulating ion transport and vascular permeability. Dysregulation of gamma-adducin impacts cellular architecture and signaling pathways, contributing to diseases involving structural or functional defects in the actin-spectrin cytoskeleton. Its broad expression and functional versatility highlight its importance in cellular and systemic homeostasis.
Related Products
ADD3 antibody
Ver Producto
Recombinant Human ADD3
Ver Producto
Gamma-Adducin (ADD3) Antibody
Rabbit polyclonal antibody against ADD3 protein. Immunogen region is Internal.
Ver Producto