Galanin Receptor Type 1 (GALR1) Antibody (Biotin)

Este producto es parte de GALR- Galanin Receptor
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169€ (20 µg)

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935106861
info@markelab.com
name
Galanin Receptor Type 1 (GALR1) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx335765
tested applications
ELISA

Description

GALR1 Antibody (Biotin) is a Rabbit Polyclonal against GALR1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Galanin Receptor Type 1 (GALR1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P47211
Gene ID
2587
Alias
GALR1,GALNR,GALNR1,GAL1 receptor
Background
Antibody anti-GALR1
Status
RUO

Descripción

GALR1 is a G protein-coupled receptor (GPCR) that binds the neuropeptide galanin, mediating inhibitory signaling through coupling to Gi/o proteins. This interaction reduces intracellular cyclic AMP (cAMP) levels and modulates potassium and calcium channels, resulting in neuronal hyperpolarization and inhibition of neurotransmitter release. GALR1 is widely expressed in the central nervous system (CNS), including the hippocampus, hypothalamus, and spinal cord, where it regulates processes like pain modulation, mood regulation, and feeding behavior. In pain pathways, GALR1 activation suppresses nociceptive transmission, providing antinociceptive effects. GALR1 also exhibits neuroprotective properties in neurodegenerative disorders, such as Alzheimer’s disease, by reducing excitotoxicity. In cancer, GALR1 acts as a tumor suppressor, particularly in head and neck squamous cell carcinoma, where its activation inhibits cell proliferation and induces apoptosis. Dysregulation of GALR1 signaling is associated with mood disorders, including depression and anxiety, where impaired inhibitory signaling contributes to emotional imbalance. Its role in pain modulation, neuroprotection, and tumor suppression positions GALR1 as a promising therapeutic target for neurological disorders, pain management, and cancer therapy.

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