G1/S-Specific Cyclin-E1 Phospho-Thr395 (CCNE1 pT395) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
G1/S-Specific Cyclin-E1 Phospho-Thr395 (CCNE1 pT395) Antibody is a rabbit polyclonal antibody against G1/S-Specific Cyclin-E1 Phospho-Thr395 (CCNE1 pT395). Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:T395.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | G1/S-Specific Cyclin-E1 Phospho-Thr395 (CCNE1 pT395) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Thr395 |
| Recommended Dilution | WB: 1/500 - 1/3000, IHC: 1/50 - 1/100, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P24864 |
| Background | Antibody anti-CCNE1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Related Products
CCNE1 antibody
Ver Producto
G1/S-Specific Cyclin-E1 Phospho-Thr395 (CCNE1 pT395) Antibody
CCNE1 (pT395) Antibody is a Rabbit Polyclonal antibody against CCNE1 (pT395). The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
Ver Producto
Cyclin E1 (CCNE1) Antibody
Cyclin E1 antibody detects endogenous levels of total Cyclin E1. CCNE1 a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Two alternatively spliced isoforms have been described.
Ver Producto