G-Protein Coupled Receptor 94 (GPR94) Antibody

Background

P2RY13 is a G protein-coupled receptor primarily activated by ADP and related nucleotides. It couples to Gi proteins, inhibiting adenylate cyclase, reducing cAMP levels, and modulating downstream cellular responses. P2RY13 is expressed in immune cells, liver, and the central nervous system, where it regulates lipid metabolism, immune responses, and energy homeostasis. In the liver, P2RY13 plays a key role in cholesterol metabolism by mediating the uptake of high-density lipoproteins (HDL), contributing to cholesterol homeostasis. In immune cells, P2RY13 regulates chemotaxis, cytokine production, and inflammation. Dysregulation of P2RY13 has been linked to lipid disorders, atherosclerosis, and inflammatory diseases. Its role in immune and metabolic regulation makes P2RY13 a promising therapeutic target for managing hyperlipidemia, atherosclerosis, and chronic inflammatory conditions. Understanding its signaling mechanisms could provide novel therapeutic avenues for metabolic and immune-related diseases.