Adhesion G Protein-Coupled Receptor D2 (ADGRD2) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Adhesion G Protein-Coupled Receptor D2 (ADGRD2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015304
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against GPR144 protein. Immunogen region is N-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adhesion G Protein-Coupled Receptor D2 (ADGRD2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q7Z7M1 |
| Gene ID | 347088 |
| Alias | ADGRD2,adhesion G protein-coupled receptor D2,adhesion G protein-coupled receptor D2, pseudogene,GPR144,G protein-coupled receptor 144,PGR24 |
| Background | Antibody anti-ADGRD2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ADGRD2, also referred to as GPR144, is another adhesion GPCR predominantly expressed in the central nervous system and reproductive tissues. Similar to ADGRD1, it contains a GAIN domain responsible for receptor cleavage and activation. ADGRD2 has been implicated in neurodevelopmental processes such as synaptic formation, axonal pathfinding, and neural connectivity. The receptor is also involved in modulating immune responses by interacting with extracellular matrix components and other cell surface proteins. It likely signals through cAMP and calcium-dependent pathways, regulating cellular homeostasis and proliferation. Though less studied compared to ADGRD1, ADGRD2's altered expression has been observed in certain cancers and inflammatory disorders, suggesting its potential role in pathology and as a candidate for targeted drug therapies.
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