G-Protein Coupled Receptor 125 (GPR125) Antibody

Background

ADGRA3, also known as GPR125, is widely expressed in stem cells, reproductive tissues, and certain endothelial cell populations. Like other adhesion GPCRs, ADGRA3 features a GAIN domain and mediates interactions with extracellular matrix proteins. This receptor is involved in stem cell regulation, particularly in germline and neural progenitor cells, and may influence tissue regeneration and repair. ADGRA3 has been implicated in Wnt signaling, contributing to cellular differentiation and development. Recent research highlights its potential role in tumorigenesis and immune cell modulation. ADGRA3's expression patterns and signaling capabilities make it a promising target for regenerative medicine and cancer therapies.