Frizzled Homolog 7 (FZD7) Antibody
221€ (50 µg)
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name
Frizzled Homolog 7 (FZD7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx325707
tested applications
ELISA, WB, IF/ICC
Description
FZD7 Antibody is a Rabbit Polyclonal against FZD7.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Frizzled Homolog 7 (FZD7) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75084 |
| Gene ID | 8324 |
| Alias | FZD7,Frizzled Homolog 7,FzE3,frizzled family receptor 7,Fzd7,Fz7 |
| Background | Antibody anti-FZD7 |
| Status | RUO |
Descripción
FZD7 is a Wnt receptor involved in both canonical β-catenin-dependent signaling and non-canonical pathways, playing a critical role in cell proliferation, migration, and stem cell maintenance. It is highly expressed in embryonic tissues, intestinal epithelium, and cancer cells. FZD7 regulates intestinal stem cell renewal and differentiation, contributing to gut homeostasis and regeneration. In cancer, FZD7 is overexpressed in tumors such as gastric, colorectal, and hepatocellular carcinomas, where it drives Wnt/β-catenin signaling to promote cell proliferation, survival, and therapy resistance. FZD7 also plays a role in epithelial-mesenchymal transition (EMT) and metastasis, enabling cancer cells to invade and spread. Its involvement in stem cell biology highlights its importance in tissue repair and cancer stem cell maintenance. Additionally, FZD7 regulates non-canonical signaling pathways like planar cell polarity (PCP), controlling cell migration and polarity during development. Targeting FZD7 has been proposed as a therapeutic strategy to inhibit Wnt signaling in cancer and regenerative medicine, as its dysregulation contributes to tumorigenesis and disease progression.
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