Frizzled Homolog 10 (FZD10) Antibody
52€ (10 µg)
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Name
Frizzled Homolog 10 (FZD10) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015245
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against FZD10 protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Frizzled Homolog 10 (FZD10) Immunogen: The antiserum was produced against synthesized peptide derived from internal of human FZD10. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9ULW2 |
| Alias | FZD10,Frizzled Homolog 10,Fz10,FzE7,CD350,FZ-10,hFz10,Frizzled class receptor 10 |
| Background | Antibody anti-FZD10 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FZD10 is a Wnt receptor predominantly mediating canonical Wnt/β-catenin signaling, playing crucial roles in embryogenesis, tissue regeneration, and tumor progression. It is highly expressed in the nervous system, skeletal tissues, and certain cancers. During development, FZD10 regulates processes like cell proliferation, differentiation, and tissue patterning, particularly in neural and skeletal systems. In cancer, FZD10 is overexpressed in tumors such as synovial sarcoma, colorectal cancer, and hepatocellular carcinoma, where it drives Wnt/β-catenin signaling to promote cell survival, proliferation, and metastasis. Its expression correlates with poor prognosis, therapy resistance, and enhanced tumor progression. FZD10 also plays roles in tissue repair and regeneration by regulating stem cell behavior and promoting cell renewal. Targeting FZD10 with monoclonal antibodies and small-molecule inhibitors is being explored as a therapeutic approach for Wnt-driven cancers, particularly synovial sarcoma. Dysregulation of FZD10 contributes to developmental defects, cancer metastasis, and tissue-specific diseases, highlighting its importance in both normal development and disease pathology.
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