Frizzled Homolog 10 (FZD10) Antibody

Este producto es parte de FZD - Frizzled Homolog
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52€ (10 µg)

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935106861
info@markelab.com
name
Frizzled Homolog 10 (FZD10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015245
tested applications
ELISA, WB

Description

Rabbit polyclonal antibody against FZD10 protein. Immunogen region is Internal.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Frizzled Homolog 10 (FZD10)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500 - 1/3000, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Size 1
10 µg
Size 2
100 µg
Size 3
200 µg
Size 4
300 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9ULW2
Alias
FZD10,Frizzled Homolog 10,Fz10,FzE7,CD350,FZ-10,hFz10,Frizzled class receptor 10
Background
Antibody anti-FZD10
Status
RUO
Note
Concentration: 1 mg/ml - 

Descripción

FZD10 is a Wnt receptor predominantly mediating canonical Wnt/β-catenin signaling, playing crucial roles in embryogenesis, tissue regeneration, and tumor progression. It is highly expressed in the nervous system, skeletal tissues, and certain cancers. During development, FZD10 regulates processes like cell proliferation, differentiation, and tissue patterning, particularly in neural and skeletal systems. In cancer, FZD10 is overexpressed in tumors such as synovial sarcoma, colorectal cancer, and hepatocellular carcinoma, where it drives Wnt/β-catenin signaling to promote cell survival, proliferation, and metastasis. Its expression correlates with poor prognosis, therapy resistance, and enhanced tumor progression. FZD10 also plays roles in tissue repair and regeneration by regulating stem cell behavior and promoting cell renewal. Targeting FZD10 with monoclonal antibodies and small-molecule inhibitors is being explored as a therapeutic approach for Wnt-driven cancers, particularly synovial sarcoma. Dysregulation of FZD10 contributes to developmental defects, cancer metastasis, and tissue-specific diseases, highlighting its importance in both normal development and disease pathology.

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