Free Fatty Acid Receptor 1 (FFAR1) Antibody

Este producto es parte de FFAR - Free Fatty Acid Receptor
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169€ (20 µg)

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935106861
info@markelab.com
name
Free Fatty Acid Receptor 1 (FFAR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx334167
tested applications
ELISA, IHC, IF/ICC

Description

FFAR1 Antibody is a Rabbit Polyclonal against FFAR1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Free Fatty Acid Receptor 1 (FFAR1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
IHC: 1/200 - 1/500, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O14842
Gene ID
2864
Alias
FFAR1,GPR40,FFA1R,G protein-coupled receptor 40
Background
Antibody anti-FFAR1
Status
RUO

Descripción

FFAR1, also known as GPR40, is a G protein-coupled receptor primarily expressed in pancreatic β-cells, where it mediates the effects of medium- and long-chain free fatty acids (FFAs). FFAR1 activation enhances glucose-stimulated insulin secretion through Gq-mediated signaling pathways, including activation of phospholipase C (PLC), increased intracellular calcium, and protein kinase C (PKC) signaling. It plays a critical role in metabolic regulation by linking dietary fat intake to insulin release, thereby maintaining glucose homeostasis. FFAR1 is a promising therapeutic target for type 2 diabetes, where selective agonists are being explored to enhance insulin secretion without causing hypoglycemia. In addition to its metabolic role, FFAR1 is expressed in the brain and has been linked to neuroprotective functions. Dysregulation of FFAR1 signaling contributes to insulin resistance, obesity, and inflammation. Its dual role in metabolic regulation and neurological health positions FFAR1 as a key target for diabetes treatment and potential neurodegenerative therapies.

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