Forkhead Box Protein E3 (FOXE3) Antibody
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Description
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Forkhead Box Protein E3 (FOXE3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13461 |
| Background | Antibody anti-FOXE3 |
| Status | RUO |
Descripción
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Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle(PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation(By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm(By similarity). Is required for morphogenesis and differentiation of the anterior segment of the eye(By similarity).
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