Follicle Stimulating Hormone Receptor (FSHR) Antibody
819€ (1 ml)
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Name
Follicle Stimulating Hormone Receptor (FSHR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx172455
Tested Applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Follicle Stimulating Hormone Receptor (FSHR) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | FSHR,Follitropin receptor,LGR1 ,FSH-R,FSHRO,ODG1 |
| Background | Antibody anti-FSHR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FSHR is a G protein-coupled receptor that binds follicle-stimulating hormone (FSH), a glycoprotein hormone essential for reproductive function. FSHR is primarily expressed in ovarian granulosa cells and testicular Sertoli cells, where it regulates gametogenesis, follicular development, and estrogen production. In females, FSHR activation stimulates granulosa cell proliferation, estradiol synthesis, and follicular maturation, critical for ovulation and fertility. In males, FSHR promotes Sertoli cell function and spermatogenesis. FSHR signaling occurs through Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and downstream activation of PKA and MAPK pathways. Mutations in FSHR can cause reproductive disorders such as ovarian dysgenesis, primary ovarian insufficiency, and male infertility. FSHR overexpression has been observed in ovarian cancer, where it may contribute to tumor growth. Therapeutically, FSH analogs are used in assisted reproduction technologies to stimulate ovarian function, while FSHR inhibitors are under investigation for treating hormone-driven cancers.
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