Follicle Stimulating Hormone Receptor (FSHR) Antibody
286€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Follicle Stimulating Hormone Receptor (FSHR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx103914
Tested Applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Follicle Stimulating Hormone Receptor (FSHR).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Follicle Stimulating Hormone Receptor (FSHR) Immunogen: FSHR (Cys18-Pro113) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23945 |
| Alias | FSHR,Follitropin receptor,LGR1 ,FSH-R,FSHRO,ODG1 |
| Background | Antibody anti-FSHR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FSHR is a G protein-coupled receptor that binds follicle-stimulating hormone (FSH), a glycoprotein hormone essential for reproductive function. FSHR is primarily expressed in ovarian granulosa cells and testicular Sertoli cells, where it regulates gametogenesis, follicular development, and estrogen production. In females, FSHR activation stimulates granulosa cell proliferation, estradiol synthesis, and follicular maturation, critical for ovulation and fertility. In males, FSHR promotes Sertoli cell function and spermatogenesis. FSHR signaling occurs through Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and downstream activation of PKA and MAPK pathways. Mutations in FSHR can cause reproductive disorders such as ovarian dysgenesis, primary ovarian insufficiency, and male infertility. FSHR overexpression has been observed in ovarian cancer, where it may contribute to tumor growth. Therapeutically, FSH analogs are used in assisted reproduction technologies to stimulate ovarian function, while FSHR inhibitors are under investigation for treating hormone-driven cancers.
Productos relacionados
Follicle Stimulating Hormone Receptor (FSHR) Antibody
FSHR Antibody is a Rabbit Polyclonal antibody against FSHR. FSHR, also named as LGR1, belongs to the G-protein coupled r…
Ver producto
Follicle Stimulating Hormone Receptor (FSHR) Antibody
Rabbit polyclonal antibody against FSHR protein. Immunogen region is Internal.…
Ver producto
Follicle Stimulating Hormone Receptor (FSHR) Antibody
Rabbit polyclonal antibody against FSHR protein. Immunogen region is Internal.…
Ver producto