Fibroblast Growth Factor 23 (FGF23) Antibody (HRP)

Este producto es parte de FGF23 - Fibroblast Growth Factor 23
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169€ (20 µg)

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935106861
info@markelab.com
name
Fibroblast Growth Factor 23 (FGF23) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx108961
tested applications
ELISA

Description

Fibroblast growth factor 23 Antibody (HRP) is a Rabbit Polyclonal antibody against Fibroblast growth factor 23 conjugated to HRP.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Fibroblast Growth Factor 23 (FGF23)
Host
Rabbit
Reactivity
Rat
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
HRP
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q8VI82
Gene ID
170583
Alias
ADHR,FGFN,HYPF,HFTC2,HPDR2,PHPTC,Phosphatonin,Tumor-derived hypophosphatemia-inducing factor
Background
Antibody anti-FGF23
Status
RUO

Descripción

FGF23 is a phosphaturic hormone primarily secreted by osteocytes and osteoblasts in bone tissue. It regulates phosphate homeostasis and vitamin D metabolism by reducing phosphate reabsorption in the kidneys and suppressing the synthesis of 1,25-dihydroxyvitamin D. FGF23 binds to its receptor in the presence of α-Klotho, promoting phosphate excretion to maintain serum phosphate levels. Elevated FGF23 levels are associated with chronic kidney disease (CKD), where impaired renal function leads to hyperphosphatemia and secondary hyperparathyroidism. Mutations in FGF23 can cause disorders like hypophosphatemic rickets and osteomalacia, characterized by bone mineralization defects. FGF23’s role in phosphate balance and bone health makes it a key target for managing CKD and related mineral metabolism disorders.

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