Fc Fragment Of IgG Low Affinity IIIb Receptor (FCGR3B) Antibody (PE)
585€ (100 tests)
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935106861
info@markelab.com
name
Fc Fragment Of IgG Low Affinity IIIb Receptor (FCGR3B) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx270858
tested applications
FCM
Description
Fc Fragment Of IgG Low Affinity IIIb Receptor (FcgR3B) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against Fc Fragment Of IgG Low Affinity IIIb Receptor (FcgR3B) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Fc Fragment Of IgG Low Affinity IIIb Receptor (FCGR3B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | CD16,FCG3,CD16A,CD16b,FCGR3,CD16-I,FCGR3A,FCR-10,FCRIII,FCRIIIb,Low affinity immunoglobulin gamma Fc region receptor III-B,Fc-gamma RIII-beta,IgG Fc receptor III-1 |
| Background | Antibody anti-FCGR3B |
| Status | RUO |
Descripción
FCGR3B, or Fc gamma receptor IIIb, is a low-affinity receptor for the Fc portion of immunoglobulin G (IgG) antibodies, primarily expressed on neutrophils. It is a member of the Fc gamma receptor (FcγR) family, which plays a pivotal role in mediating immune responses through the recognition of the Fc region of IgG antibodies. FCGR3B is one of the two isoforms of FcγRIII, the other being FCGR3A (CD16A). While both isoforms share sequence similarity and belong to the same gene family, they have distinct tissue distributions, membrane anchoring mechanisms, and functional roles in the immune system. FCGR3B is especially important for facilitating immune complex clearance, phagocytosis, and neutrophil activation, processes that are crucial in maintaining immune homeostasis and defending against pathogens. Dysregulation of FCGR3B or mutations in its gene have been associated with a range of clinical conditions, including autoimmune diseases and chronic inflammatory disorders
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