Fc Fragment Of IgG Low Affinity IIIb Receptor (FCGR3B) Antibody

Este producto es parte de FCGR3B - Fc gamma receptor IIIb
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Fc Fragment Of IgG Low Affinity IIIb Receptor (FCGR3B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx145933
tested applications
ELISA, WB

Description

FCGR3B Antibody is a Rabbit Polyclonal against FCGR3B.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Fc Fragment Of IgG Low Affinity IIIb Receptor (FCGR3B)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
BC128562
Alias
CD16,FCG3,CD16A,CD16b,FCGR3,CD16-I,FCGR3A,FCR-10,FCRIII,FCRIIIb,Low affinity immunoglobulin gamma Fc region receptor III-B,Fc-gamma RIII-beta,IgG Fc receptor III-1
Background
Antibody anti-FCGR3B
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. - 

Descripción

FCGR3B, or Fc gamma receptor IIIb, is a low-affinity receptor for the Fc portion of immunoglobulin G (IgG) antibodies, primarily expressed on neutrophils. It is a member of the Fc gamma receptor (FcγR) family, which plays a pivotal role in mediating immune responses through the recognition of the Fc region of IgG antibodies. FCGR3B is one of the two isoforms of FcγRIII, the other being FCGR3A (CD16A). While both isoforms share sequence similarity and belong to the same gene family, they have distinct tissue distributions, membrane anchoring mechanisms, and functional roles in the immune system. FCGR3B is especially important for facilitating immune complex clearance, phagocytosis, and neutrophil activation, processes that are crucial in maintaining immune homeostasis and defending against pathogens. Dysregulation of FCGR3B or mutations in its gene have been associated with a range of clinical conditions, including autoimmune diseases and chronic inflammatory disorders

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