Fc Fragment of IgG, Low Affinity IIc, Receptor For (CD32) (FCGR2C) Antibody

Background

FCGR2C (Fc gamma receptor IIc), also known as CD32C, is a member of the Fc gamma receptor (FcγR) family, which binds to the Fc portion of immunoglobulin G (IgG). This receptor is of significant interest due to its functional variability and implications in immune regulation. FCGR2C is a low-affinity receptor and, unlike other Fc gamma receptors, is expressed in only a subset of immune cells due to complex regulation at the genetic and transcriptional levels. FCGR2C is unique because it arises from a combination of genetic recombination between its closely related genes, FCGR2A (an activating receptor) and FCGR2B (an inhibitory receptor), resulting in hybrid characteristics. The FCGR2C gene is located on chromosome 1q23, a region where other Fcγ receptor family members are also found. This region is known for its genetic variability, contributing to differential expression of these receptors in the population. While FCGR2C was originally thought to be a pseudogene in many individuals, subsequent studies revealed that a significant proportion of the population expresses a functional receptor due to specific genetic recombination events.