Fc Fragment Of IgA Receptor / CD89 (FCAR) Antibody (PE)
585€ (100 tests)
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Name
Fc Fragment Of IgA Receptor / CD89 (FCAR) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270850
Tested Applications
FCM
Description
Fc Fragment Of IgA Receptor (FcaR) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against Fc Fragment Of IgA Receptor (FcaR) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Fc Fragment Of IgA Receptor / CD89 (FCAR) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | CD89,FcalphaR,FcalphaRI,CTB-61M7.2,Immunoglobulin alpha Fc receptor, IgA Fc receptor |
| Background | Antibody anti-FCAR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The Fc alpha receptor (FCAR), also known as CD89, is a receptor protein expressed on the surface of certain immune cells, primarily neutrophils, monocytes, macrophages, and some dendritic cells. This receptor binds specifically to the Fc region of immunoglobulin A (IgA), the most abundant antibody found in mucosal secretions and an essential player in immune responses in the gastrointestinal and respiratory tracts. The interaction between CD89 and IgA is critical for initiating immune responses such as phagocytosis, cytokine production, and antibody-dependent cellular cytotoxicity (ADCC). The FCAR gene encoding CD89 is located on chromosome 19q13, and it belongs to the immunoglobulin (Ig) superfamily. The biological significance of CD89 lies in its role as a primary mediator of IgA-dependent immune mechanisms, making it essential in mucosal immunity and in the clearance of pathogens from the body.
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