Fc Fragment Of IgA Receptor / CD89 (FCAR) Antibody
299€ (0.1 mg)
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935106861
info@markelab.com
name
Fc Fragment Of IgA Receptor / CD89 (FCAR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx140347
tested applications
FCM
Description
CD89 Antibody is a Mouse Monoclonal against CD89.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Fc Fragment Of IgA Receptor / CD89 (FCAR) |
| Host | Mouse |
| Reactivity | Human, Monkey |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 Kappa |
| Clone ID | O385 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P24071 |
| Gene ID | 2204 |
| Alias | CD89,FcalphaR,FcalphaRI,CTB-61M7.2,Immunoglobulin alpha Fc receptor, IgA Fc receptor |
| Background | Antibody anti-FCAR |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
The Fc alpha receptor (FCAR), also known as CD89, is a receptor protein expressed on the surface of certain immune cells, primarily neutrophils, monocytes, macrophages, and some dendritic cells. This receptor binds specifically to the Fc region of immunoglobulin A (IgA), the most abundant antibody found in mucosal secretions and an essential player in immune responses in the gastrointestinal and respiratory tracts. The interaction between CD89 and IgA is critical for initiating immune responses such as phagocytosis, cytokine production, and antibody-dependent cellular cytotoxicity (ADCC). The FCAR gene encoding CD89 is located on chromosome 19q13, and it belongs to the immunoglobulin (Ig) superfamily. The biological significance of CD89 lies in its role as a primary mediator of IgA-dependent immune mechanisms, making it essential in mucosal immunity and in the clearance of pathogens from the body.
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This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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