Exosome Complex Exonuclease DIS3 (DIS3) Antibody
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Description
Dis3 Mitotic Control Homolog (S. Cerevisiae) Antibody is a Rabbit Polyclonal antibody against Dis3 Mitotic Control Homolog (S. Cerevisiae).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Exosome Complex Exonuclease DIS3 (DIS3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y2L1 |
| Gene ID | 22894 |
| NCBI Accession | NP_001121698.1, NM_001128226.2, NP_055768.3, NM_014953.4 |
| OMIM | 607533 |
| Background | Antibody anti-DIS3 |
| Status | RUO |
Descripción
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Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts(PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination(CSR) and/or Ig variable region somatic hypermutation(SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.
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Dis3 Mitotic Control Homolog (S. Cerevisiae) Antibody is a Rabbit Polyclonal antibody against Dis3 Mitotic Control Homolog (S. Cerevisiae).
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