Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation 6 (ERCC6) Antibody
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Description
ERCC6 Antibody is a Rabbit Polyclonal against ERCC6.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation 6 (ERCC6) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/40000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q03468 |
| Gene ID | 2074 |
| Background | Antibody anti-ERCC6 |
| Status | RUO |
Descripción
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ERCC6 antibody
Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex(DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.
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Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation 6 (ERCC6) Antibody
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