Escherichia coli J5 Lipopolysaccharide (LPS) Antibody
377€ (100 µg)
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935106861
info@markelab.com
name
Escherichia coli J5 Lipopolysaccharide (LPS) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx411324
tested applications
ELISA, WB
Description
Mouse monoclonal antibody against LPS from O111:B4 J5 strain of E. coli. This strain has no O-specific chains, containing only the core LPS structure.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Escherichia coli J5 Lipopolysaccharide (LPS) |
| Host | Mouse |
| Reactivity | Bacteria |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b |
| Purification | Purified by Protein G. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing < 0.1% sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | LPS |
| Background | Antibody anti-LPS |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
Lipopolysaccharides (LPS) are large molecules found in the outer membrane of Gram-negative bacteria, playing a crucial role in the structural integrity of bacterial cells and acting as a potent activator of the immune system. Composed of lipid A, a core oligosaccharide, and an O-antigen polysaccharide, LPS is a critical factor in bacterial pathogenicity. Lipid A is the bioactive component that triggers immune responses by binding to the Toll-like receptor 4 (TLR4) complex on immune cells, leading to the activation of nuclear factor-kappa B (NF-κB) and the release of pro-inflammatory cytokines such as IL-6 and TNF-alpha. While LPS is essential for host defense, its excessive activation can result in septic shock, characterized by systemic inflammation, organ failure, and high mortality. Therapeutic strategies targeting LPS-TLR4 signaling pathways are being explored to manage sepsis and other inflammatory conditions.
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