Endothelin 1 (EDN1) Antibody
357.5€ (100 µg)
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Name
Endothelin 1 (EDN1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx122972
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the EDN1 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Endothelin 1 (EDN1) Immunogen: Recombinant fragment corresponding to 50-212 AA of human EDN1. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 24 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC009720 |
| Alias | ARCND3,ET1, ET-1,HDLCQ7,QME,PPET1 |
| Background | Antibody anti-EDN1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Endothelin-1 (EDN1) is a peptide hormone belonging to the endothelin family. It plays a crucial role in regulating blood vessel contraction and dilation, thereby influencing blood pressure and blood flow throughout the body. Endothelin-1 is primarily produced by endothelial cells, It is also produced by other cell types, including vascular smooth muscle cells, cardiomyocytes, and certain inflammatory cells.Endothelin-1 acts as a potent vasoconstrictor, meaning it causes blood vessels to narrow, leading to an increase in blood pressure. Dysregulation of endothelin-1 signaling is associated with several cardiovascular disorders, including hypertension, atherosclerosis, coronary artery disease, and pulmonary hypertension. Elevated levels of endothelin-1 have been observed in individuals with these conditions, contributing to their pathogenesis. Endothelin-1 is able to bind to specific receptors on target cells known as endothelin receptors. There are two main types of endothelin receptors: endothelin receptor type A (ETA) and endothelin receptor type B (ETB).
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