EEPH Receptor A8 (EPHA8) Antibody
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Description
Eph Receptor A8 Antibody is a Rabbit Polyclonal antibody against Eph Receptor A8.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | EEPH Receptor A8 (EPHA8) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29322 |
| Gene ID | 2046 |
| NCBI Accession | NP_001006944.1, NM_001006943.2, NP_065387.1, NM_020526.4 |
| OMIM | 176945 |
| Background | Antibody anti-EPHA8 |
| Status | RUO |
Descripción
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Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth(By similarity).
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Eph Receptor A8 Antibody is a Rabbit Polyclonal antibody against Eph Receptor A8.
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