E3 Ubiquitin-Protein Ligase UBR1 (UBR1) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
E3 Ubiquitin-Protein Ligase UBR1 (UBR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx014447
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against UBR1 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | E3 Ubiquitin-Protein Ligase UBR1 (UBR1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8IWV7 |
| Background | Antibody anti-UBR1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.
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