E-Selectin / CD62E (SELE) Antibody
338€ (100 µg)
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Name
E-Selectin / CD62E (SELE) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx019077
Tested Applications
WB, IF/ICC
Description
CD62E Antibody is a Rabbit Polyclonal antibody against Human, Mouse and Rat.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: E-Selectin / CD62E (SELE) Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the N-terminal of human E-Selectin. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Immunogen affinity purified. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | WB, IF/ICC |
| Buffer | TBS, pH 7.4, 0.5% BSA, 40% glycerol and 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P16581 |
| Gene ID | 6401 |
| OMIM | 131210 |
| Alias | ELAM,ESEL,CD62E,ELAM1,LECAM2,selectin-e,E-selectin,CD62 antigen-like family member E,Endothelial leukocyte adhesion molecule 1,Leukocyte-endothelial cell adhesion molecule 2 |
| Background | Antibody anti-SELE |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Selectin E (SELE) is an adhesion molecule expressed on activated endothelial cells in response to inflammatory cytokines such as TNF-α and IL-1β, playing a pivotal role in the recruitment of leukocytes to sites of inflammation. It mediates the rolling and tethering of leukocytes on the endothelium by binding to specific glycoprotein ligands on the surface of leukocytes, such as PSGL-1, facilitating their migration into tissues. SELE is crucial in early-stage inflammatory responses and is involved in various pathophysiological processes, including atherosclerosis, autoimmune diseases, and cancer metastasis. Dysregulation of SELE expression has been associated with increased endothelial dysfunction and vascular inflammation, contributing to the development of cardiovascular diseases. Its expression is transient and tightly regulated by transcriptional mechanisms, ensuring that leukocyte recruitment occurs precisely during inflammatory responses. Therapeutic targeting of SELE has been explored to mitigate excessive inflammation, with strategies focusing on blocking its interaction with ligands to prevent leukocyte adhesion and infiltration. Additionally, SELE is being investigated as a biomarker for endothelial activation and vascular inflammation in conditions such as sepsis and chronic inflammatory disorders. Its role in mediating cell adhesion under shear stress highlights its importance in maintaining vascular integrity during immune surveillance and inflammatory responses.
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