Human B-Cell Differentiation Antigen CD72 (CD72) Protein
403€ (2 µg)
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Name
Human B-Cell Differentiation Antigen CD72 (CD72) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx263522
Description
CD72 is a recombinant protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | B-Cell Differentiation Antigen CD72 (CD72) |
| Host | E. coli |
| Assay Type | Activity: Not tested |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Size 1 | 2 µg |
| Size 2 | 5 µg |
| Size 3 | 10 µg |
| Form | Liquid |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P21854 |
| Alias | LYB2,CD72b,B-cell differentiation antigen CD72 |
| Background | Protein CD72 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD72 is a type II transmembrane glycoprotein belonging to the C-type lectin superfamily. It is mainly expressed on the surface of B cells, as well as some other immune cells such as dendritic cells. CD72 serves as a negative regulator of B cell receptor (BCR) signaling, modulating immune responses by attenuating excessive B cell activation and preventing autoimmunity. CD72 interacts with protein tyrosine phosphatases, including SHP-1 and SHP-2, through its immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic domain. When activated, CD72 negatively regulates BCR signaling, contributing to the maintenance of immune tolerance and B cell homeostasis. Given its central role in B cell regulation, CD72 is involved in autoimmune diseases, chronic inflammatory conditions, and lymphomas.
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