Dopamine Receptor D5 (DRD5) Antibody
637€ (100 µl)
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Name
Dopamine Receptor D5 (DRD5) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx112162
Tested Applications
ELISA, WB
Description
Dopamine Receptor D5 Antibody is a Rabbit Polyclonal antibody against Dopamine Receptor D5.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Dopamine Receptor D5 (DRD5) Immunogen: Human DRD5. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21918 |
| Gene ID | 1816 |
| OMIM | 126453 |
| Alias | DRD5,DRD1B,DRD1L2,D(1B) dopamine receptor,dopamine receptor 5,Gpcr1,DBDR |
| Background | Antibody anti-DRD5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
DRD5 is a G protein-coupled receptor of the D1-like dopamine receptor family that couples to Gs proteins, leading to activation of adenylate cyclase and an increase in cyclic AMP (cAMP) levels. DRD5 is highly expressed in limbic brain regions, including the hippocampus, hypothalamus, and cerebral cortex, where it modulates cognition, memory, and emotional behavior. DRD5 has a higher affinity for dopamine compared to DRD1, allowing it to regulate synaptic transmission and plasticity more effectively. It plays a key role in learning, working memory, and behavioral flexibility, with its dysfunction linked to schizophrenia, cognitive deficits, and neurological disorders. DRD5 is also involved in regulating motor function and reward pathways, contributing to the dopaminergic control of behavior. In peripheral tissues, DRD5 is expressed in renal, cardiovascular, and immune systems, where it regulates sodium balance, blood pressure, and immune cell activity. Dysregulation of DRD5 signaling has been associated with hypertension and autoimmune diseases. DRD5 is a potential therapeutic target for neuropsychiatric disorders, cognitive impairment, and cardiovascular dysfunction, given its role in dopamine-mediated signaling and cellular homeostasis.
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