Dopamine Receptor D4 (DRD4) Antibody

Este producto es parte de DRD - Dopamine Receptor D
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949€ (100 µl)

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935106861
info@markelab.com
name
Dopamine Receptor D4 (DRD4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx022562
tested applications
ELISA, WB, IF/ICC

Description

D4 Dopamine Receptor Antibody is a Rabbit polyclonal antibody for neuroscience against D4 Dopamine Receptor.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Dopamine Receptor D4 (DRD4)
Host
Rabbit
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Neat.
Size 1
100 µl
Form
Lyophilized
Tested Applications
ELISA, WB, IF/ICC
Buffer
Buffer contains no preservative.
Availability
Shipped within 10-20 working days.
Storage
Store at -20 °C or -80 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
DRD4,d(2C) dopamine receptor,dopamine receptor 4,D4R
Background
Antibody anti-DRD4
Status
RUO

Descripción

DRD4 is a Gi/o-coupled G protein-coupled receptor of the D2-like dopamine receptor family, primarily expressed in brain regions associated with cognition, emotion, and reward, such as the prefrontal cortex, amygdala, and hippocampus. DRD4 plays a significant role in modulating attention, impulse control, and executive function, and its dysfunction has been linked to attention-deficit hyperactivity disorder (ADHD), schizophrenia, and other neuropsychiatric disorders. Notably, DRD4 is highly polymorphic, with variations in its gene (e.g., the 7-repeat allele) associated with ADHD susceptibility, novelty-seeking behavior, and addiction. DRD4 signaling inhibits adenylate cyclase activity, leading to reduced cyclic AMP (cAMP) levels, and influences downstream pathways like MAPK and protein kinase C (PKC), regulating neuronal excitability and plasticity. In addiction, DRD4 contributes to reward sensitivity and reinforcement learning, making it a target for substance abuse treatment. DRD4 is also expressed in peripheral tissues, where it modulates cardiovascular function and immune responses. Its polymorphic nature and role in attention and behavior make DRD4 a key target for ADHD therapeutics and neuropsychiatric research.

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