Dopamine Receptor D3 (DRD3) Antibody

Este producto es parte de DRD - Dopamine Receptor D
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221€ (50 µg)

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935106861
info@markelab.com
name
Dopamine Receptor D3 (DRD3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx327542
tested applications
ELISA, WB

Description

DRD3 Antibody is a Rabbit Polyclonal against DRD3.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Dopamine Receptor D3 (DRD3)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
ELISA: 1/20000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P35462
Gene ID
1814
Alias
DRD3,D3DR,ETM1,FET1,D3 receptor,dopamine D3 receptor,dopaminergic receptor D3
Background
Antibody anti-DRD3
Status
RUO

Descripción

DRD3 is a G protein-coupled receptor (GPCR) of the D2-like family that couples to Gi/o proteins, inhibiting adenylate cyclase activity and reducing intracellular cyclic AMP (cAMP) levels. It is primarily expressed in limbic regions of the brain, including the ventral striatum, nucleus accumbens, and olfactory tubercle, where it regulates emotional behavior, reward processing, and cognitive function. DRD3 is involved in motivation, reinforcement learning, and drug addiction, where its dysregulation contributes to compulsive behaviors and substance abuse disorders. In schizophrenia, altered DRD3 signaling is associated with cognitive and behavioral deficits, and it is a target for atypical antipsychotics. DRD3 also plays a role in Parkinson’s disease, where it regulates motor control and is upregulated in response to dopaminergic neuron loss, contributing to dyskinesia. Outside the brain, DRD3 is expressed in peripheral tissues, including the kidney and immune cells, where it influences renal function and immune responses. DRD3 is a promising therapeutic target for neuropsychiatric disorders, Parkinson’s disease, and addiction, with specific agonists and antagonists under development to modulate its function.

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