Dopamine Receptor D3 (DRD3) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
DRD3 Antibody is a Rabbit Polyclonal antibody against DRD3. This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Dopamine Receptor D3 (DRD3) |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35462 |
| Gene ID | 1814 |
| NCBI Accession | NP_000787.2 |
| Alias | DRD3,D3DR,ETM1,FET1,D3 receptor,dopamine D3 receptor,dopaminergic receptor D3 |
| Background | Antibody anti-DRD3 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
DRD3 is a G protein-coupled receptor (GPCR) of the D2-like family that couples to Gi/o proteins, inhibiting adenylate cyclase activity and reducing intracellular cyclic AMP (cAMP) levels. It is primarily expressed in limbic regions of the brain, including the ventral striatum, nucleus accumbens, and olfactory tubercle, where it regulates emotional behavior, reward processing, and cognitive function. DRD3 is involved in motivation, reinforcement learning, and drug addiction, where its dysregulation contributes to compulsive behaviors and substance abuse disorders. In schizophrenia, altered DRD3 signaling is associated with cognitive and behavioral deficits, and it is a target for atypical antipsychotics. DRD3 also plays a role in Parkinson’s disease, where it regulates motor control and is upregulated in response to dopaminergic neuron loss, contributing to dyskinesia. Outside the brain, DRD3 is expressed in peripheral tissues, including the kidney and immune cells, where it influences renal function and immune responses. DRD3 is a promising therapeutic target for neuropsychiatric disorders, Parkinson’s disease, and addiction, with specific agonists and antagonists under development to modulate its function.
Related Products
Rat DRD3 (Dopamine Receptor D3) ELISA Kit
Ver Producto
Dopamine Receptor D3 (DRD3) Antibody
DRD3 Antibody is a Rabbit Polyclonal antibody against DRD3. This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
Ver Producto
Human Dopamine Receptor D3 (DRD3) ELISA Kit
Human Dopamine Receptor D3 (DRD3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Dopamine Receptor D3 (DRD3) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Dopamine Receptor D3 (DRD3)
Ver Producto