Dopamine Receptor D1 (DRD1) Antibody (FITC)
169€ (20 µg)
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Name
Dopamine Receptor D1 (DRD1) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx314815
Description
DRD1 Antibody (FITC) is a Rabbit Polyclonal against DRD1 conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Dopamine Receptor D1 (DRD1) Immunogen: Recombinant Human D (1A) dopamine receptor protein (338-446AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21728 |
| Gene ID | 1812 |
| OMIM | 126449 |
| Alias | DRD1,D1A,DADR,Gpcr15,dopamine D1 receptor,Dopamine-1A receptor,D1 receptor,Drd-1,Drd1a |
| Background | Antibody anti-DRD1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
DRD1 is a G protein-coupled receptor (GPCR) that belongs to the D1-like receptor family and is the most abundant dopamine receptor in the central nervous system (CNS). It is primarily expressed in brain regions such as the striatum, prefrontal cortex, and hippocampus, where it modulates motor control, cognition, and reward signaling. DRD1 couples to Gs proteins, leading to activation of adenylate cyclase, which increases intracellular cyclic AMP (cAMP) levels and activates protein kinase A (PKA) pathways. DRD1 signaling enhances synaptic plasticity, learning, and memory formation and plays a key role in mediating motivation and reinforcement behaviors. Dysregulation of DRD1 activity has been implicated in neuropsychiatric disorders, including schizophrenia, attention-deficit hyperactivity disorder (ADHD), and drug addiction, where abnormal dopaminergic transmission disrupts behavior and cognition. In Parkinson’s disease, reduced DRD1 signaling contributes to motor dysfunction due to dopamine depletion. DRD1 is also involved in cardiovascular regulation and renal function, influencing blood pressure and sodium balance. Pharmacological targeting of DRD1 with agonists or antagonists has therapeutic potential for neurological disorders, such as Parkinson’s and schizophrenia, as well as cardiovascular conditions.
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