Dog Vascular Endothelial Growth Factor A (VEGFA) Protein
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935106861
info@markelab.com
Precio
533€ (50 µg)
Protein VEGFA
proveedor
Abbexareference
abx069630Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Vascular Endothelial Growth Factor A (VEGFA) is a recombinant Dog protein produced in a Prokaryotic expression system (E. coli).
Background
VEGFA is a key member of the vascular endothelial growth factor (VEGF) family and plays a crucial role in angiogenesis, vascular permeability, and endothelial cell proliferation VEGFA binds primarily to its receptors VEGFR-1 and VEGFR-2, triggering signaling pathways like PI3K/AKT and ERK/MAPK to promote blood vessel formation during embryonic development, wound healing, and tissue repair Dysregulated VEGFA expression is associated with pathological angiogenesis observed in cancer, diabetic retinopathy, and age-related macular degeneration (AMD) VEGFA also increases vascular permeability by altering endothelial junctions, contributing to fluid leakage in conditions such as inflammation and tumors Targeted therapies, such as bevacizumab and other anti-VEGF agents, inhibit VEGFA activity to suppress angiogenesis and tumor growth in various cancers and ocular diseases
Características del producto
category
Proteins and Peptides
origin
Dog
host
E. coli
immunogen target
Vascular Endothelial Growth Factor A (VEGFA)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
500 µg
size 5
1 mg
observerd MW
Molecular Weight: Calculated MW: 19.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala27-Arg190 Tag: N-terminal His tag
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
VEGFA
dry ice
No
availability
Shipped within 5-7 working days.
alias
L-VEGF,MVCD1,VEGF,VPF,Vascular permeability factor
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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