Dog Vascular Endothelial Growth Factor A (VEGFA) Protein

Este producto es parte de VEGFA - Vascular Endothelial Growth Factor A
Dog Vascular Endothelial Growth Factor A (VEGFA) Protein
533€ (50 µg)

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Name
Dog Vascular Endothelial Growth Factor A (VEGFA) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx069630
Tested Applications
WB, SDS-PAGE

Description

Dog Vascular Endothelial Growth Factor A (VEGFA) is a recombinant Dog protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Vascular Endothelial Growth Factor A (VEGFA)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Ala27-Arg190
Tag: N-terminal His tag
Origin
Dog
Conjugation
Unconjugated
Observed MW
Calculated MW: 19.1 kDa
Expression
Recombinant
Purity
> 95%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q9MYV3
Alias
L-VEGF,MVCD1,VEGF,VPF,Vascular permeability factor
Background
Protein VEGFA
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

VEGFA is a key member of the vascular endothelial growth factor (VEGF) family and plays a crucial role in angiogenesis, vascular permeability, and endothelial cell proliferation VEGFA binds primarily to its receptors VEGFR-1 and VEGFR-2, triggering signaling pathways like PI3K/AKT and ERK/MAPK to promote blood vessel formation during embryonic development, wound healing, and tissue repair Dysregulated VEGFA expression is associated with pathological angiogenesis observed in cancer, diabetic retinopathy, and age-related macular degeneration (AMD) VEGFA also increases vascular permeability by altering endothelial junctions, contributing to fluid leakage in conditions such as inflammation and tumors Targeted therapies, such as bevacizumab and other anti-VEGF agents, inhibit VEGFA activity to suppress angiogenesis and tumor growth in various cancers and ocular diseases

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