Dog Vascular Cell Adhesion Molecule 1 (VCAM1) ELISA Kit

Dog Vascular Cell Adhesion Molecule 1 (VCAM1) ELISA Kit

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935106861

info@markelab.com

Precio

687.5€ (96 tests)

proveedor

Abbexa

reference

abx258011

Tested Applications

ELISA

reactivity

Dog

status

RUO

clonality

Descripción

Dog Vascular Cell Adhesion Molecule 1 / CD106 (VCAM1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Dog Vascular Cell Adhesion Molecule 1 / CD106 (VCAM1) concentrations in serum, plasma, tissue homogenates and other biological fluids.

Background

Vascular cell adhesion protein 1, also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106), is a human protein encoded by the VCAM1 gene. VCAM-1 plays a critical role in interacting with the integrin very late antigen-4 (VLA4).VCAM-1 is responsible for facilitating the adhesion of various immune cells, including lymphocytes, monocytes, eosinophils, and basophils, to the endothelial blood vessel. Additionally, it plays a vital role in signal transduction between leukocytes and endothelial cells, and it has been implicated in the development of conditions such as atherosclerosis and rheumatoid arthritis. Ectodomain release of VCAM-1 is observed in various situations and is often mediated by enzymes like matrix metalloproteinases (MMPs) and ADAMs (A Disintegrin and Metalloproteinase). This release can be triggered by external factors such as calcium ionophores, cytokines, and growth factors. VCAM-1 is also known by the alias CD106

Background

La proteína de adhesión de células vasculares 1, también conocida como molécula de adhesión de células vasculares 1 (VCAM-1) o Cluster de diferenciación 106 (CD106), es una proteína humana codificada por el gen VCAM1. VCAM-1 desempeña un papel fundamental en la interacción de la integrina (VLA4 Very late Antigen-4). VCAM-1 es responsable de facilitar la adhesión de varias células inmunitarias, incluidos linfocitos, monocitos, eosinófilos y basófilos, al vaso sanguíneo endotelial. . Además, desempeña un papel vital en la transducción de señales entre leucocitos y células endoteliales, y se ha implicado en el desarrollo de enfermedades como la aterosclerosis y la artritis reumatoide. La liberación de ectodominio de VCAM-1 se observa en diversas situaciones y, a menudo, está mediada por enzimas como las metaloproteinasas de matriz (MMP) y ADAM (desintegrina A y metaloproteinasa). Esta liberación puede ser provocada por factores externos como ionóforos de calcio, citocinas y factores de crecimiento. VCAM-1 también es conocido con el alias CD106

Características del producto

category

ELISA Kits


immunogen target

Vascular Cell Adhesion Molecule 1 (VCAM1)


reactivity

Dog


test range

3.12 ng/ml - 200 ng/ml


sensitivity

< 1.14 ng/ml


assay type

Sandwich


assay data

Quantitative


detection method

Colorimetric


sample type

Serum,Plasma,Tissue homogenates,Other biological fluids


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

V-CAM 1,VCAM-1,INCAM-100,CD106


storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit


or code

VCAM1


dry ice

No


note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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reference

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