Dog Interleukin 10 (IL10) Protein

Pida mas información
935106861
info@markelab.com
Precio
442€ (50 µg)
Protein IL10
proveedor
Abbexareference
abx166344Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Dog Interleukin 10 Protein is a recombinant Dog protein expressed in E. coli.
Background
IL10 is an anti-inflammatory cytokine produced by macrophages, T regulatory cells, and other immune cells to suppress excessive immune responses and maintain tissue homeostasis IL10 signaling occurs through the IL-10 receptor (IL10R) and activates the JAK/STAT3 pathway, inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL1β, and IL6 It plays a pivotal role in immune tolerance, limiting damage caused by chronic inflammation and infections Dysregulation of IL10 expression is associated with autoimmune diseases, such as Crohn's disease, multiple sclerosis, and psoriasis IL10 also exerts immunosuppressive effects in the tumor microenvironment, facilitating tumor progression and immune evasion due to its inhibitory influence on T cells and antigen-presenting cells IL10-based therapies are being explored for managing inflammatory diseases and promoting immune modulation in cancer and chronic infections
Características del producto
category
Proteins and Peptides
origin
Dog
host
E. coli
immunogen target
Interleukin 10 (IL10)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
500 µg
size 5
1 mg
observerd MW
Molecular Weight: Calculated MW: 49.0 kDa Observed MW: 49 kDa Concentration: Prior to lyophilization: 300 µg/ml Sequence Fragment: Arg21-Ile181 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 80%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL10
dry ice
No
availability
Shipped within 5-7 working days.
alias
CSIF,GVHDS,IL-10,IL10A,TGIF,Cytokine synthesis inhibitory factor
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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