Dog Beta-1 adrenergic receptor (ADRB1) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Dog Beta-1 adrenergic receptor (ADRB1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx515006
tested applications
ELISA
Description
Dog Beta-1 adrenergic receptor (ADRB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Dog Beta-1 adrenergic receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Beta-1 adrenergic receptor (ADRB1) |
| Reactivity | Dog |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P79148 |
| Alias | ADRB1,ADRB1R,Adrenergic receptor beta 1,RHR,B1AR,FNSS2,BETA1AR |
| Background | Elisa kits for ADRB1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
The adrenergic receptor beta-1 (ADRB1) is a G-protein-coupled receptor that plays a critical role in cardiovascular physiology. Predominantly expressed in the heart, kidneys, and adipose tissues, ADRB1 mediates the effects of catecholamines such as epinephrine and norepinephrine. Upon activation, ADRB1 stimulates adenylate cyclase through Gs proteins, leading to increased cAMP production. This process enhances heart rate (positive chronotropy), contractility (positive inotropy), and conduction velocity (positive dromotropy), making it essential for the regulation of cardiac output. ADRB1 also influences renin secretion from the kidneys, impacting blood pressure regulation. Polymorphisms in the ADRB1 gene, such as Ser49Gly and Arg389Gly, have been linked to altered receptor activity, influencing individual responses to stress, exercise, and beta-blocker therapies. Dysregulation or overstimulation of ADRB1 is associated with conditions such as hypertension, heart failure, and arrhythmias, underscoring its significance as a therapeutic target in cardiovascular diseases.
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