Docking Protein 9 (DOCK9) Antibody

Este producto es parte de DOCK - Dedicator of Cytokinesis
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364€ (100 µg)

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935106861
info@markelab.com
name
Docking Protein 9 (DOCK9) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx232499
tested applications
ELISA, WB, IHC, IF/ICC

Description

DOCK9 Antibody is a Rabbit Polyclonal against DOCK9.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Docking Protein 9 (DOCK9)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by immunogen affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9BZ29
Gene ID
23348
OMIM
607325
Alias
ZIZ1,ZIZIMIN1,DOCK9, KIAA1058
Background
Antibody anti-DOCK9
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

DOCK9, also known as Zizimin1, functions as a GEF for Cdc42, regulating actin remodeling, filopodia formation, and cell polarity. It is widely expressed in tissues, including the brain, where it controls neurite outgrowth, axonal guidance, and synaptic development. DOCK9 interacts with membrane phosphoinositides like PIP3 for activation, linking signaling pathways to cytoskeletal changes. It plays roles in epithelial cell migration and endothelial barrier stability. Dysregulation of DOCK9 is linked to neurological defects and cancer progression through disrupted cytoskeletal control and altered cell adhesion. Knockdown studies reveal impaired filopodia formation, cell spreading, and neuronal development.
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