anti- DOCK9 antibody

Este producto es parte de DOCK - Dedicator of Cytokinesis
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935106861
info@markelab.com
name
anti- DOCK9 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02499
tested applications
ELISA, WB, IHC, IF

Description

Guanine nucleotide-exchange factor(GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

Category
Primary Antibodies
Immunogen Target
dedicator of cytokinesis 9
Host
Rabbit
Reactivity
human,mouse,rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
200-236 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC, IF
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q9BZ29
Gene ID
23348
Alias
ZIZ1,ZIZIMIN1,DOCK9, KIAA1058
Background
Antibody anti-DOCK9
Status
RUO
Note
This product is for research use only.

Descripción

DOCK9, also known as Zizimin1, functions as a GEF for Cdc42, regulating actin remodeling, filopodia formation, and cell polarity. It is widely expressed in tissues, including the brain, where it controls neurite outgrowth, axonal guidance, and synaptic development. DOCK9 interacts with membrane phosphoinositides like PIP3 for activation, linking signaling pathways to cytoskeletal changes. It plays roles in epithelial cell migration and endothelial barrier stability. Dysregulation of DOCK9 is linked to neurological defects and cancer progression through disrupted cytoskeletal control and altered cell adhesion. Knockdown studies reveal impaired filopodia formation, cell spreading, and neuronal development.
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