Docking Protein 4 (DOK4) Antibody
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Description
Docking Protein 4 Antibody is a Rabbit Polyclonal antibody against Docking Protein 4.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Docking Protein 4 (DOK4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TEW6 |
| Gene ID | 55715 |
| OMIM | 608333 |
| Alias | Downstream of tyrosine kinase 4,Insulin receptor substrate 5,IRS-5,IRS5 |
| Background | Antibody anti-DOK4 |
| Status | RUO |
Descripción
DOK4 is an adaptor protein belonging to the DOK family, involved in signal transduction downstream of receptor tyrosine kinases, such as RET and insulin receptors. It modulates pathways like MAPK/ERK and PI3K/Akt, influencing cellular proliferation, survival, and differentiation. DOK4 is expressed in tissues like skeletal muscle, adipose tissue, and the nervous system, where it regulates metabolic signaling and cellular responses. It acts as a negative regulator of signaling by binding to SH2 domains and inhibiting downstream activation. Dysregulation of DOK4 is associated with metabolic disorders, insulin resistance, and certain cancers, where it influences cell adhesion and motility.
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