DOCK3; MOCA Antibody
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935106861
info@markelab.com
Precio
364€ (100 µg)
Antibody anti-DOCK3
proveedor
Abbexareference
abx232494Tested Applications
ELISA, WBreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
DOCK3; MOCA Antibody is a Rabbit Polyclonal against DOCK3; MOCA.
Background
DOCK3, or MOCA, is a neuron-specific GEF for Rac1 that regulates neurite outgrowth, axonal growth, and synaptic plasticity in the CNS. It mediates actin rearrangement, promoting axonal guidance and dendritic remodeling. Highly expressed in neurons, DOCK3 maintains synapse connectivity and supports neuroprotection. Dysregulation contributes to neurodegenerative diseases like Alzheimer’s, where it influences tau phosphorylation and cell survival pathways such as ERK/Akt activation. DOCK3 deficiency causes motor and cognitive impairments in mouse models, highlighting its role in neuronal development, CNS recovery, and axonal regeneration.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
DOCK3; MOCA
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purity
≥ 95% (SDS-PAGE)
purification
Purified by immunogen affinity chromatography.
recommended dilution
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
size 1
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
DOCK3
dry ice
No
availability
Shipped within 5-12 working days.
alias
DOCK3, MOCA, PBP, Dock3, dedicator of cytokinesis 3, NEDIDHA
uniprot id
note
Concentration: 2 mg/ml - Validity: 12 months.
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