DOCK180-Specific Antibody
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935106861
info@markelab.com
Precio
364€ (100 µg)
Antibody anti-DOCK1
proveedor
Abbexareference
abx232493Tested Applications
ELISA, WB, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
DOCK180-Specific Antibody is a Rabbit Polyclonal against DOCK180-Specific.
Background
DOCK1, also known as DOCK180, is a GEF that activates Rac1 GTPase, regulating cytoskeleton rearrangement and cell migration. It forms a DOCK1–ELMO–Crk complex for Rac1 activation, driving lamellipodia formation and cell motility. DOCK1 is crucial for phagocytosis, cell polarity, neural crest migration, and cardiovascular development. Overexpression links to cancer metastasis by promoting tumor motility. It localizes to cytoplasm and membrane ruffles during migration and is regulated via phosphorylation and scaffold interactions. Knockout studies in mice reveal its role in embryonic viability, neuronal differentiation, and immune responses, highlighting its importance in cell adhesion and morphology.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
DOCK180-Specific
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IF/ICC
purity
≥ 95% (SDS-PAGE)
purification
Purified by immunogen affinity chromatography.
recommended dilution
WB: 1/500 - 1/2400, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
size 1
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
DOCK1
dry ice
No
availability
Shipped within 5-12 working days.
alias
DOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1
uniprot id
note
Concentration: 2 mg/ml - Validity: 12 months.
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