DOCK180-Specific Antibody
364€ (100 µg)
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935106861
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name
DOCK180-Specific Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx232493
tested applications
ELISA, WB, IF/ICC
Description
DOCK180-Specific Antibody is a Rabbit Polyclonal against DOCK180-Specific.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DOCK180-Specific |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2400, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14185 |
| Gene ID | 1793 |
| OMIM | 601403 |
| Alias | DOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1 |
| Background | Antibody anti-DOCK1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
DOCK1, also known as DOCK180, is a GEF that activates Rac1 GTPase, regulating cytoskeleton rearrangement and cell migration. It forms a DOCK1–ELMO–Crk complex for Rac1 activation, driving lamellipodia formation and cell motility. DOCK1 is crucial for phagocytosis, cell polarity, neural crest migration, and cardiovascular development. Overexpression links to cancer metastasis by promoting tumor motility. It localizes to cytoplasm and membrane ruffles during migration and is regulated via phosphorylation and scaffold interactions. Knockout studies in mice reveal its role in embryonic viability, neuronal differentiation, and immune responses, highlighting its importance in cell adhesion and morphology.
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