DNA damage-binding protein 2 (DDB2) Antibody
299€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
DNA damage-binding protein 2 (DDB2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx402261
Tested Applications
ELISA, WB, IHC, FCM
Description
DNA damage-binding protein 2 (DDB2) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human DDB2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: DNA damage-binding protein 2 (DDB2) Immunogen: A synthesized peptide derived from Human DDB2 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, FCM: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92466 |
| Gene ID | 1643 |
| OMIM | 278740 |
| Alias | XPE,DDBB,UV-DDB2,UV-damaged DNA-binding protein 2,Damage-specific DNA-binding protein 2,DDB p48 subunit |
| Background | Antibody anti-DDB2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Damage-specific DNA binding protein 2 (DDB2) is a substrate recognition protein that works in concert with DDB1 within the UV-DDB complex, a subset of the CUL4-DDB1 E3 ubiquitin ligase system. DDB2 plays an essential role in nucleotide excision repair (NER) by recognizing UV-induced DNA damage, such as cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts, and recruiting repair factors to the damage site. Its high affinity for damaged DNA and ability to induce chromatin remodeling are key to facilitating repair processes. DDB2 also mediates the ubiquitination and degradation of histones and other chromatin-associated proteins, promoting access to damaged DNA. Mutations or dysregulation of DDB2 have been linked to xeroderma pigmentosum group E (XP-E), a condition characterized by extreme sensitivity to UV light and a high predisposition to skin cancer. Beyond DNA repair, DDB2 is implicated in cell cycle regulation and apoptosis, highlighting its multifunctional role in maintaining genomic integrity.
Productos relacionados
DNA Damage-Binding Protein 2 (DDB2) Antibody
DDB2 Antibody is a Rabbit Polyclonal antibody against DDB2. This gene encodes a protein that is necessary for the repair…
Ver producto Damage Specific DNA Binding Protein 2 (DDB2) Antibody
Damage-Specific Dna Binding Protein 2, 48 kDa Antibody is a Rabbit Polyclonal antibody against Damage-Specific Dna Bindi…
Ver producto
Damage Specific DNA Binding Protein 2 (DDB2) Antibody
Damage Specific DNA Binding Protein 2 Antibody is a Rabbit Polyclonal against Damage Specific DNA Binding Protein 2.…
Ver producto