DNA Damage-Binding Protein 1 (DDB1) Antibody (FITC)
169€ (20 µg)
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Name
DNA Damage-Binding Protein 1 (DDB1) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx335377
Description
DDB1 Antibody (FITC) is a Rabbit Polyclonal against DDB1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: DNA Damage-Binding Protein 1 (DDB1) Immunogen: Recombinant Human DNA damage-binding protein 1 protein (741-943AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16531 |
| Gene ID | 1642 |
| Alias | XPE,DDBA,XAP1,XPCE,XPE-BF,UV-DDB1,WHIKERS,UV-damaged DNA-binding factor,DNA damage-binding protein a,DDB p127 subunit |
| Background | Antibody anti-DDB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Damage-specific DNA binding protein 1 (DDB1) is a critical component of the ubiquitin-proteasome system, serving as a scaffold protein within the CUL4-DDB1 E3 ubiquitin ligase complex. DDB1 interacts with various substrate receptors, including members of the DCAF (DDB1 and CUL4-associated factors) family, to mediate the recognition and ubiquitination of target proteins. Its role is pivotal in regulating DNA repair, particularly nucleotide excision repair (NER), where it facilitates the removal of UV-induced photoproducts and bulky DNA adducts. DDB1 also contributes to the degradation of proteins involved in transcriptional regulation, cell cycle progression, and genome stability. Structurally, DDB1 contains WD40 domains that mediate interactions with CUL4 and substrate receptors, ensuring versatility and specificity in substrate selection. Dysregulation of DDB1 has been associated with genomic instability and cancer development. Its ubiquitous expression highlights its fundamental role in cellular homeostasis and DNA damage response pathways.
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