Disrupted In Schizophrenia 1 Protein (DISC1) Antibody
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Description
Disrupted In Schizophrenia 1 Protein (DISC1) Antibody is a Rabbit Polyclonal antibody against Disrupted In Schizophrenia 1 Protein (DISC1).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Disrupted In Schizophrenia 1 Protein (DISC1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NRI5 |
| Alias | DISC1, C1orf136, SCZD9, disrupted in schizophrenia 1, DISC1 scaffold protein |
| Background | Antibody anti-DISC1 |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
Disrupted in schizophrenia 1 (DISC1) is a scaffolding protein with diverse roles in neurodevelopment, synaptic function, and adult neurogenesis. Originally identified in a Scottish family with a high incidence of schizophrenia, DISC1 has since been implicated in several psychiatric disorders, including bipolar disorder and major depression. DISC1 interacts with multiple molecular partners, influencing signaling pathways involved in neuronal proliferation, migration, and axonal growth. Additionally, it regulates mitochondrial function and intracellular trafficking. Dysfunctional DISC1 has been associated with structural brain abnormalities, synaptic deficits, and altered neuronal connectivity, which are common features in neuropsychiatric disorders. The multifaceted roles of DISC1 in cellular processes and its potential as a biomarker or therapeutic target underscore its significance in neuroscience and psychiatry research.
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Disrupted In Schizophrenia 1 Protein (DISC1) Antibody
DISC1 Antibody is a Rabbit Polyclonal antibody against DISC1. This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Disrupted In Schizophrenia 1 Protein (DISC1) Antibody
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t (1;11) (q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]. This antibody is supplied as crude ascites.
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