DENND1C Antibody (FITC)
169€ (20 µg)
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name
DENND1C Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx317488
Description
DENND1C Antibody (FITC) is a Rabbit Polyclonal against DENND1C conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DENND1C |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8IV53 |
| Gene ID | 79958 |
| NCBI Accession | NP_001277260.1, NM_001290331.1, NP_079174.2, NM_024898.3 |
| OMIM | 613634 |
| Alias | FAM31C,Connecdenn 3 ,Protein FAM31C |
| Background | Antibody anti-DENND1C |
| Status | RUO |
Descripción
DENN domain containing 1C (DENND1C) functions as a guanine nucleotide exchange factor (GEF) for Rab GTPases, primarily Rab35, and is essential for regulating endosomal recycling, membrane dynamics, and vesicular trafficking processes. Through its DENN domain, DENND1C facilitates the activation of Rab35 by catalyzing the exchange of GDP for GTP, ensuring proper vesicle sorting and transport within the cell. It plays a key role in cytokinesis by contributing to the recycling of plasma membrane components required for cell division. DENND1C is also involved in receptor recycling, signal transduction, and membrane trafficking, which are critical for maintaining cellular homeostasis. Its expression across a variety of tissues indicates its broad functionality, but recent research highlights its specific roles in immune responses, including antigen presentation and cytokine signaling. Dysregulation of DENND1C has been associated with defects in membrane trafficking and signaling, suggesting potential links to immune disorders and cellular stress responses.
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