Delta-type opioid receptor (OPRD1) Antibody
299€ (50 µl)
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935106861
info@markelab.com
name
Delta-type opioid receptor (OPRD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx402527
tested applications
ELISA, WB
Description
Delta-type opioid receptor (OPRD1) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human, Mouse OPRD1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Delta-type opioid receptor (OPRD1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41143 |
| Gene ID | 4985 |
| OMIM | 165195 |
| Alias | OPRD1,DOP,DOR,OP1,Delta receptor,DOR-1,DOPr,opioid receptor,OPRD |
| Background | Antibody anti-OPRD1 |
| Status | RUO |
Descripción
OPRD1, also known as the delta-opioid receptor, is a G protein-coupled receptor (GPCR) activated by endogenous opioid peptides such as enkephalins. It is expressed in the central nervous system (CNS), including the cortex, limbic system, and spinal cord, where it modulates pain perception, mood regulation, and neuroprotection. OPRD1 couples to Gi/o proteins, inhibiting adenylate cyclase activity, reducing cAMP levels, and modulating ion channel activity to decrease neuronal excitability. Activation of OPRD1 produces analgesic effects, particularly in chronic and neuropathic pain conditions. It is also involved in regulating mood and emotional behaviors, with potential roles in reducing anxiety and depressive symptoms. Dysregulation of OPRD1 has been linked to pain disorders, addiction, and mood dysregulation. Selective OPRD1 agonists are being explored for their analgesic properties with lower addiction potential compared to mu-opioid receptor agonists. OPRD1 modulation represents a promising therapeutic approach for pain management, mood disorders, and neuroprotection.
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