Defender Against Cell Death 1 (DAD1) Antibody (Biotin)
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Description
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 Antibody (Biotin) is a Rabbit Polyclonal antibody against Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 conjugated to Biotin.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Defender Against Cell Death 1 (DAD1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P61803 |
| Gene ID | 1603 |
| OMIM | 600243 |
| Background | Antibody anti-DAD1 |
| Status | RUO |
Descripción
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DAD1 antibody
Essential subunit of the N-oligosaccharyl transferase(OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum(ER). Loss of the DAD1 protein triggers apoptosis(By similarity).
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Defender Against Cell Death 1 (DAD1) Antibody
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq].
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Defender Against Cell Death 1 (DAD1) Antibody (Biotin)
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 Antibody (Biotin) is a Rabbit Polyclonal antibody against Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 conjugated to Biotin.
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