Dedicator of Cytokinesis Protein 10 (DOCK10) Antibody

Este producto es parte de DOCK - Dedicator of Cytokinesis
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Dedicator of Cytokinesis Protein 10 (DOCK10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx145342
tested applications
ELISA, IHC

Description

DOCK10 Antibody is a Rabbit Polyclonal against DOCK10.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Dedicator of Cytokinesis Protein 10 (DOCK10)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
BC015018
Alias
DOCK10, KIAA0694, ZIZ3,Zizimin-3,DRIP2, Nbla10300
Background
Antibody anti-DOCK10
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

DOCK10 is a GEF for Rac1 and Cdc42, involved in regulating actin cytoskeletal dynamics, cell migration, and lymphocyte polarization. It is highly expressed in hematopoietic cells and epithelial tissues, promoting B-cell activation, dendritic cell migration, and immune surveillance. DOCK10 mediates filopodia and lamellipodia formation, enhancing membrane protrusion during cell migration. It is implicated in immune responses, particularly in B and T cells, where it supports polarization and chemotaxis. Dysregulation is associated with immune dysfunction and cancer metastasis through enhanced cell motility. Knockout models show defects in lymphocyte migration and immune cell activation.
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