Death Domain Associated Protein / DAP6 (Daxx) Antibody
325€ (0.1 mg)
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Name
Death Domain Associated Protein / DAP6 (Daxx) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139393
Tested Applications
WB, IF/ICC, IP
Description
Daxx Antibody is a Mouse Monoclonal against Daxx.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Death Domain Associated Protein / DAP6 (Daxx) Immunogen: His6-tagged protein corresponding to amino acids 580-740 of Human Daxx. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | C938 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IF/ICC, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q9UER7 |
| Gene ID | 1616 |
| Alias | DAXX, BING2, DAP6, EAP1, death-domain associated protein, death domain associated protein, SMIM40 |
| Background | Antibody anti-DAXX |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Death-Associated Protein 6 (DAXX) is a multifunctional protein involved in apoptosis regulation, transcriptional control, and chromatin remodeling. Initially identified as a Fas-binding protein, DAXX can mediate apoptotic signals in response to Fas receptor activation, playing a role in programmed cell death. In addition to its role in apoptosis, DAXX functions as a transcriptional co-repressor, interacting with various transcription factors to modulate gene expression. DAXX is also a key component of the chromatin remodeling machinery, where it interacts with histone chaperones and contributes to histone deposition and nucleosome assembly. It is localized to promyelocytic leukemia nuclear bodies (PML-NBs) and telomeres, where it participates in DNA damage responses and telomere maintenance. Dysregulation of DAXX is linked to cancer, as it can act as a tumor suppressor or promoter depending on the cellular context. Mutations in DAXX are frequently observed in pancreatic neuroendocrine tumors and other cancers, where they contribute to genomic instability and altered gene expression. DAXX is being investigated as a therapeutic target due to its diverse roles in apoptosis, chromatin dynamics, and tumorigenesis.
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