DDB1 And CUL4 Associated Factor 6 (DCAF6) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
DDB1 And CUL4 Associated Factor 6 (DCAF6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx212972
tested applications
ELISA, IHC
Description
DCAF6 Antibody is a Rabbit Polyclonal against DCAF6.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DDB1 And CUL4 Associated Factor 6 (DCAF6) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q58WW2 |
| Gene ID | 55827 |
| Alias | NRIP,ARCAP,IQWD1,PC326,MSTP055,Nuclear receptor interaction protein,IQ motif and WD repeat-containing protein 1,Androgen receptor complex-associated protein |
| Background | Antibody anti-DCAF6 |
| Status | RUO |
Descripción
DDB1 and CUL4 associated factor 6 (DCAF6), also known as TCEB3C, acts as a substrate receptor for the CUL4-DDB1 E3 ubiquitin ligase complex and is involved in the regulation of transcriptional activity and cellular signaling. DCAF6 interacts with nuclear receptors and transcription factors, mediating their ubiquitination and subsequent degradation to modulate gene expression. It is particularly noted for its role in steroid hormone receptor signaling, where it interacts with androgen and glucocorticoid receptors, influencing hormone-responsive gene networks. DCAF6 is broadly expressed across tissues, with high relevance in hormonal regulation and stress responses. Its dysregulation has been associated with diseases such as cancer, where altered nuclear receptor signaling contributes to tumor progression. Research into DCAF6 continues to uncover its diverse roles in transcriptional regulation and its potential as a therapeutic target.
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