DDB1 And CUL4 Associated Factor 6 (DCAF6) Antibody

Background

DDB1 and CUL4 associated factor 6 (DCAF6), also known as TCEB3C, acts as a substrate receptor for the CUL4-DDB1 E3 ubiquitin ligase complex and is involved in the regulation of transcriptional activity and cellular signaling. DCAF6 interacts with nuclear receptors and transcription factors, mediating their ubiquitination and subsequent degradation to modulate gene expression. It is particularly noted for its role in steroid hormone receptor signaling, where it interacts with androgen and glucocorticoid receptors, influencing hormone-responsive gene networks. DCAF6 is broadly expressed across tissues, with high relevance in hormonal regulation and stress responses. Its dysregulation has been associated with diseases such as cancer, where altered nuclear receptor signaling contributes to tumor progression. Research into DCAF6 continues to uncover its diverse roles in transcriptional regulation and its potential as a therapeutic target.